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Similarity & Review


Multiple Sources


Compared to VS. Not a review!

Similarity Scale

Percentage of possible points earned scored -1 to 1 in tenths in 60 categories

Genre Controls Modes Progress Builds Stages Content Aesthetic Vibe

Bio Prototype


This bioengineering themed arena wave survival game might be my favorite of the Brotato-style auto shooters so far. The logic puzzle style chaining of abilities from your "brain" gives me something enjoyable to look forward to on each round end and within the rounds the movement-only wave survival is quite enjoyable. I also dig the ugly-cute aesthetic and overall vibe, making this a title I'm looking forward to putting more time into. I think if you like Brotato and want to really think through strategy between rounds, this is a good choice. If you like "spellcrafting" games this could be considered similar. It even lets you test your build before going to the next wave!

Arena Shooter Auto-Shooter Brotato-style Bullet Heaven Content Rich Enemy Hell Roguelite Single Stick Shooter Spell Crafting Survivors-like Top Down or Isometric Wave Survival
8.5 Combined Ranking Score
13/72 Ranking Position
1436/1600 Total Points
9.3 Final Review
92% Steam
9.9 Scale
8.8 Vibes
2041 Steam Reviews
379/400 Review Points
7.6 Similarity Score
88% Diagnosis:
1057/1200 Comparison Points
100% Genre 8/8 genre
100% Simple Controls 7/7 move
85% Survival Modes 2.8/4 modes
56% Power Progression 0.5/4 level
100% Buildcrafting Depth 5/5 build
54% Stage Features 0.6/7 stage
86% Content Breadth 6.4/9 stuff
100% Aesthetics 6/6 style
98% Gameplay Vibe Check 9.5/10 vibe vibe

Bio Prototype Ranking Notes

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Scaling and Review Notes

Personal Hours Played: 4.1

Every game ranked was played, but also scaled based on research, talking to developers & your feedback. The priority with the scale's initial design was to compare similarity on relatively objective features - so it doesn't claim to include reviews of the depth and clarity you'd get at a games journalism site, nor the intensive time played you might get from player reviews on steam. We try to incorporate and link all of that along with a 'review scale' that checks for bugs. See the heatmap and breakdown! Time played noted so you can take any notes with a big grain of salt! I can't get to high level gameplay in 850+ games so I heavily research every game. Over 80 game creators let me interview or survey them! I Hope to go back and refine. Please argue or submit your own scores and reviews to be incorporated with credit into the notes and score numbers.

Added or last checked on 11/13/2023

Bio Prototype is an excellent creature creating survivors-like, though more in the Brotato-style since it does all of the upgrading on round ends and the gameplay stays within a small box-like arena. I haven't played or unlocked nearly enough of it, but it's popular enough that I was able to enjoy some nice gameplay videos and other content to help with my first impressions review.

The lack of exploration aspects may make it less similar to Vampire Survivors, as does the relatively complex upgrade system, but I found it quite satisfying both in avoiding the enemies and upgrading during my run. The enemy drops don't auto gather so it feels a tiny bit more like VS compared to Brotato. The upgrading is done by selecting from a small amount of options for "organs" to implant and then chaining them up from your "brain." This works like a simple puzzle, well simple in terms of left to right alignment but complicated in terms of the chain of events. You can sell your previous upgrades if needed (we're counting this interface as a vendor as well) and even test your ability layout between rounds.

Tweaking this brain linking to get the most heavenly of bullet heavens results in a satisfying gameplay loop that I think will keep many fans busy for a solid set of hours (this is one I intend to come back to after trying out all the games, myself.) It's also helped along by the simple in round movement controls (single stick only!) You avoid mobs and try to gather resources while also lining up your attacks without the distraction of additional controls. The enemy waves are laid out well, as in the best of these games, to make pathing the maze between them satisfying enough to pull you into the zen point (at least until the end of the round.)

There are a variety of playable creatures as well as a fair amount of variation in attacks and abilities. It has multiple stages, though as far as I know they're basically all a simple arena. There's an endless mode and a "draft" mode. It's pretty full of content which is mostly hidden at first behind a pretty simple and straight to the action main menu (something I very much appreciate to get me into the next run quickly.)

Some organs create temporary health/powerup drops so partial score there. There are a lot of challenges to unlock things, but no currency based meta unlocks as far as I know. This makes it a bit more skill and strategy based for progression than some games on this list that mostly reward time spent grinding. That can make it either more or less appealing to you, to me it's just different and sometimes I'm in the mood for one or the other. But I have to admit more obviously grind-happy games sometimes steal more hours away from me.

I think the "round end" upgrade cycle allows it a great complexity in the strategy, but that's not always my personal preference for playing these games (You'll notice I didn't particularly end up enamored with Brotato, kind of king of the round end upgrade auto shooters.) In this case, the game won me over by what I find to be a much more charming aesthetic, relatively unique system for upgrades, and the basic logic/programming puzzle of setting up moves.

Bio Prototype Similarity Scale Heatmap

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Measured in 60 categories via likert-scale style options -1 to 1 in tenths, how does this game compare to Vampire Survivors. This allows 1200 total "points". It's easier to have a point of comparison and we just picked Vampire Survivors since it's the most popular and commonly referenced game in the subgenre. For detailed methodology read the explainer. For in depth examples at score value, see the scoring guide and for term definitions see the key.

7.6 Similarity Score
88% Diagnosis:
1057/1200 Comparison Points
Rogue-lite 1/1
Auto-Fire / Auto-Battle 1/1
Real Time 1/1
Top Down or Isometric 1/1
Direct Control of Single Avatar 1/1
Arcade Style 1/1
Bullet Heaven A (Many Player Bullets) 1/1
Bullet Heaven B (Few Enemy Bullets) 1/1
One Handed Play (w Controller) 1/1
Move Only 1/1
No Dash 1/1
No Trigger 1/1
No Special Move 1/1
No Aiming 1/1
No On-Aim / On-Fire Movement Penalty 1/1
Timed / Boss Ended Survival 1/1
Endless Mode 1/1
Organic / Unannounced Waves 0/1
High Enemy Count (Horde) 0.8/1
Level Up on XP Gain Event -0.5/1
Streamlined Level Choices (Simple UI) 0/1
Currency Based Meta Unlocks 0/1
Goal Based Meta Unlocks 1/1
Build Crafting 1/1
Weapon Combination / "Evolution" 1/1
Interesting Item / Weapon / Ability Synergy 1/1
Broken / Invincible Builds Possible 1/1
Explorable Map -1/1
BIG Maps -1/1
XP on Ground 1/1
Health on Ground 0.3/1
Temp Powerups / Items on Ground 0.3/1
Treasure Chests and/or Loot Events 0/1
Vendor / Merchant on Run 1/1
Enemy Variety 0.8/1
Bosses / Elites 1/1
Many Interesting Characters 1/1
Many Challenges 1/1
Multiple Stages 0.6/1
Difficulty Modifiers 1/1
Bestiary / Lore 0/1
Achievements 1/1
Secrets 0/1
Retro / Pixel Art 1/1
Damage Numbers 1/1
Lofi Charm 1/1
Bumpin Music 1/1
Fun Writing 1/1
Subtle Humor 1/1
Panic & Zen Duo Vibe 1/1
Over the Top 1/1
"One More Run" / Short Runs 1/1
Difficulty Ramp 0.5/1
Fun Ramp 1/1
Low Price 1/1
Technical Check 1/1
Controls Check 1/1
Fun Check 1/1
Feels like VS 0.9/1

Bio Prototype Review Scale Heatmap

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The review scale is judged from -1 to 1 in 10 categories, with 200 possible "points" earned. Steam review positive percentage is worth another 100 points, and a "ten point" pure vibe review number adds extra subjectivity. Converted into points, that's 400 points total. The points aren't used directly in the ranking, though, which averages the three number scores for the final review score listed in the game line above.

9.3 Final Review
92% Positive Steam Reviews
2041 Steam Reviews
8.8 Pure Vibes
9.9 Review Scale
379/400 Review Points
Not Buggy 1/1
Not Janky 1/1
Good UI 1/1
Controller and Deck 1/1
Lots of Content 0.9/1
Good Theme 1/1
Good Graphics and Sound 1/1
Fun Feel 1/1
Unique Twists 1/1
Vibe Check 1/1

Game Features

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Listing various features we've got info on.


  • Local: No
  • Online: No
  • Player Count: 1
  • Leaderboards: Steam

Steam Features

  • Steam Cloud: Yes
  • Steam Achievements: 39
  • Steam Leaderboards: Yes
  • Steam Workshop: No
  • Steam Trading Cards: Yes

Extras, Etc.

  • NSFW: No
  • Demo Available: No
  • DLC Available: No
  • Soundtrack Available: No

Marketing Blurb

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Some description of the game and its features from the creators.

"A wave of irrational experimentation rushes toward you. Hurry up and mutate! evolution! Become scarier monsters than them! Use flesh and blood to bloom a way of survival! 24 characters, more than 80 kinds of organs, and endless build combinations"

"Hurry up and mutate! evolution! Become scarier monsters than them! Use flesh and blood to bloom a way of survival! 19 characters, more than 40 kinds of organs, and endless build combinations!"

"Link organs to your brain to create exponentially increasing combos" "More than 80 kinds of organs, 40 special designed characters, and infinite combinations"

Control Style Notes

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The game is a single stick shooter, with no options for manual aim. It's not quite as much of a mowing game, so you mostly avoid enemies while chaining projectile combos.

Automated Features


No Manual options.

Supported Controls

  • Controller: Full
  • Controller Move Only: Yes
  • Controller One Handed: Yes
  • Mouse Only: Yes
  • Keyboard Only: Yes
  • Keyboard One Handed: Yes

Game Modes

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Timed Survival

Endless Survival

Daily Challenge

Test Mode

Game Mode Notes

The primary mode is the timed round survival in the menu. When upgrading within a run, there is an option to enter a sort of test mode where you can see how your abilities end up chaining together and test the damage against dummy targets.

Run Times & Speedups

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Average Run Time: 30m

Run Time Notes

Runs are separated into 15 small rounds, with upgrades at the end of each round brotato-style. You can test your build between rounds.

Disclaimer: Hard to say exact run time from my gameplay, since I spend so much time between rounds fiddling 15 short rounds can take me 45 minutes or even an hour. Part of that is just me being silly and spending too much time in the test mode probably. "Run time "Depends on difficulty. In normal mode you can expect 20-35 minutes. You can clock over an hour in endless mode." via BrziKorak on the forum. Sounds about right.

Speed Settings


Player Power Progression

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Detailed notes on progression systems.

In Run Progression

In between rounds you are awarded a choice of "organs" which are your ability chain and weapon items. You can sell your organs and have access to a store where you can upgrade your capabilities or buy more organ picks. You then must create a programming like chain of attacks from your brain by linking organs, which you can move and rearrange as you wish between rounds.

Some organs create temporary powerups which can be picked up off the ground.

Meta Progression

Achievements unlock new "classes" and new types of organs (the way abilities and attacks chain from your characters brain, or brains rather.)